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个人基本情况
姓 名：刘伟
性 别：男
出生年月： 1978年3月
民 族：汉族
政治面貌：中共党员
职称职务：副教授
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教育经历
1996.9——2000.7 天津师范大学化学系化学教育专业（本科）
2000.9——2003.7南开大学元素所国家重点实验室（硕士）
2003.9——2006.7 清华大学化学系（博士）
2011.1——2013.4天津市国际生物医药联合研究院高通量药物筛选中心（博士后）
2013.12——2014.4 美国西弗吉尼亚大学化学系访问学者
招收研究生学科及方向
招收硕士研究生：应用化学、有机化学
从事研究的学科专业领域及主要研究方向：
学科领域
有机化学
主要研究方向
1. 药物化学及化学生物学；
2. 有机合成方法学及电化学合成；
参与与主持的主要科研项目
2008-01至2011-12 基于线性螯合功能的"假载体"脉络体系印迹识别蛋白质的研究。国家自然科学青年基金第三参与人（20704031/B040301）；
2013-01-2016-12 逆向合成指导的芳香化酶抑制剂全新药物设计和高通量虚拟筛选。国家自然科学面上基金第二参与人（21272171/B020601）；
2014-01-2016-12 苯并异噻唑酮类caspase-3抑制剂结构优化与生物活性评价。主持一项国家自然科学基金青年基金项目（21302139/B020602）。
完成的主要论文
自2000年至今，已在国内外学术刊物以第一作者、通讯作者或第二作者（通讯导师为第一作者）发表SCI收录论文20余篇。其中包括：RAPID COMMUN MASS SP; INT J MASS SPECTROM; APPL ORGANOMET CHEM; J ORGANOMET CHEM; BULL CHEM SOC JPN; BIOORGAN MED CHEM; J HETEROCYCLE CHEM; NUCLEOS NUCLEOT NUCL等国际杂志。在天津科技大学期间论文发表情况如下：
(1) Wei Liu*, Yanling Guo, Cong Han, Shaoling Cheng; 1-(4-Nitrophenyl)pyrrolidine-2-carboxamide; Acta Crystallographica Section E, 2007, 6(5), o2778-o2779.
(2) Wei Liu*, Yanling Guo, Cong Han, Xiaonan Huang; Characteristic fragmentation behavior of 5-[1-aryl-1H-pyrrol-2-yl]-1H-tetrazole by electrospray ionization tandem mass spectrometry; Life Science Journal-ACTA ZHEN, 2008, 5(2), 25-29.
(3) Wei Liu*, Yanting Tang, Yu Guo, Bo Sun, Hemin Zhu, Yanyan Xiao, Dandan Dong, Cheng Yang; Synthesis, characterization and bioactivity determination of ferrocenyl urea derivatives; Applied Organometallic Chemistry, 2012, 26, 189-193.
(4) Wei Liu*, Lin Zhang, Honggang Zhou, Cheng Yang, Zhiwei Miao, Yufen Zhao; Synthesis of Novel Nucleoside Analogue Phosphorothioamidate Prodrugs and in vitro Anticancer Evaluation Against RKO Human Colon Carcinoma Cells; Nucleosides, Nucleotides and Nucleic Acids, 2013, 32, 161-173.
(5) Dandan Dong, Yanyan Xiao, Wei Liu*, Honggang, Zhou, Cheng Yang. Progress in Kinase Aurora-B and its inhibitors; Acta Pharmaceutica Sinica, 2013, 48, 457-465.
(6) Dazhi Liu, Zhen Tian, Zhihui Yan, Lixin Wu, Yan Ma, Quan Wang, Wei Liu*, Honggang Zhou, Cheng Yang; Design, synthesis and evaluation of 1, 2-benzisothiazol-3-one derivatives as potent caspase-3 inhibitors; Bioorganic & Medicinal Chemistry, 2013, 21, 2960-2967.
(7) Sun Yuan-Pei, Zhang Ning, Wang Jian, Guo Yu, Sun Bo, Liu Wei*, Zhou Hong-Gang, Yang Cheng. Synthesis and Biological Evaluation of quinolinone compounds as SARS CoV 3CLpro inhibitors. Chinese J. Chem., 2013, 31, 1199-1206.
(8) 朱贺敏，孙晓晓，刘伟*，周红刚，杨诚. 靶标Aurora A激酶结构、功能与抑制剂研究进展. 中国药学杂志，2013，48（10），753-758.
(9) Sun Xiao-xiao, Sun Tao, Wang Tai-yi, Zhang Yan, Liu Hui-juan, Wang Quan, Niu Guo-jun, Liu Wei*, Zhou Hong-gang, Yang Cheng. Synthesis and Characterization of Pyrazoleanthrone Derivatives as Aurora A Kinase Inhibitors. Chem. Res. Chin. Univ., 2013, 29, 6: 1098-1103.
(10) Wei Liu*, He-Min Zhu, Guo-Jun Niu, En-Zhi Shi, Jie Chen, Bo Sun, Wei-Qiang Chen, Hong-Gang Zhou, Cheng Yang. Synthesis, modification and docking studies of 5-sulfonyl isatin derivatives as SARS-CoV 3C-like protease inhibitors. Bioorganic & Medicinal Chemistry, 2014, 22, 292-302.
(11) Lixin Wu, Meiqi Lu, Zhihui Yan, Xiaobin Tang, Bo Sun, Wei Liu*, Honggang Zhou, Cheng Yang. 1,2-Benzisothiazol-3-one derivatives as a novel class of small-molecule caspase-3 inhibitors. Bioorganic & Medicinal Chemistry, 2014, 22, 2416-2426.
(12) Zhenghui Li, Yang Pan, Weilong Zhong, Yunpeng Zhu, Yongle Zhao, Lixin Li, Wei Liu*, Honggang Zhou, Cheng Yang. Synthesis and evaluation of N-acyl-substituted 1,2-benzisothiazol-3-one derivatives as caspase-3 inhibitors. Bioorganic & Medicinal Chemistry, 2014, 22, 6735-6745.
(13) Zhenfei Guo, Zhihui Yan, Xiaowei Zhou, Quan Wang, Meiqi Lu, Wei Liu*, Honggang Zhou, Cheng Yang, Edward J. McClain Synthesis and biological evaluation of novel 1,2-benzisothiazol-3-one-derived 1,2,3-triazoles as caspase-3 inhibitors. Med Chem Res, 2015, 24: 1814-1829.
(14) Wei Zhao, Wei Liu*. Progresses of Weinreb Amides in Organic Synthesis. Chinese Journal of Organic Chemistry, 2015, 35, 55-69.
(15) Tang Xiaobin, Li Zhenghui, Li Yonghong, Liu Wei*, Yu Peng, Li Lixin, Guo Yu and Yang Cheng. Synthesis and Biological Evaluation of Novel Saccharin Derivatives Containing 1,2,3-Triazole Moiety. Chem. Res. Chin. Univ., 2015, 31(1), 71-77.
(16) Zhou Xiaowei, Tang Yanting, Sang Feng, Wang Jinghan, Li lixin, Zhang Xiuli, Liu Wei*, Dai Yujie. Synthesis and Biological Evaluation of Phosphotyrosyl Mimetic as a Novel PTP1B Inhibitor. Chinese Journal of Organic Chemistry, 2015, 35(6), 1363-1369.
专利申请
1,2-苯并异噻唑-3-酮1,2,3-三唑类衍生物及应用。申请号：2014101223774
联系方式
通信地址：天津市泰达开发区第十三大街29号天津科技大学6号楼403室
邮政编码：300457
手机：18920203098
电 话：022-60600812
E-mail ：liuwei2006@tust.edu.cn
