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刘伟

    个人基本情况    
  
                        

     姓 名:刘伟

     性 别:男

     出生年月: 19783

     民 族:汉族

     政治面貌:中共党员

     职称:副教授

 

    教育经历


     1996.9
——2000.7 天津师范大学化学系化学教育专业(本科)

     2000.9——2003.7南开大学元素所国家重点实验室(硕士)

     2003.9——2006.7 清华大学化学系(博士)

     2011.1——2013.4天津市国际生物医药联合研究院高通量药物筛选中心(博士后)

     2013.12——2014.4  美国西弗吉尼亚大学化学系访问学者


    招收研究生学科及方向


     招收硕士研究生:应用化学、有机化学

 


    从事研究的学科专业领域及主要研究方向:


    学科领域


     有机化学

 
    主要研究方向


     1.
药物化学及化学生物学;

     2. 有机合成方法学及电化学合成;


    参与与主持的主要科研项目


     2008-01
2011-12   基于线性螯合功能的"假载体"脉络体系印迹识别蛋白质的研究。国家自然科学青年基金第三参与人(20704031/B040301);

     2013-01-2016-12  逆向合成指导的芳香化酶抑制剂全新药物设计和高通量虚拟筛选。国家自然科学面上基金第二参与人(21272171/B020601);

     2014-01-2016-12  苯并异噻唑酮类caspase-3抑制剂结构优化与生物活性评价。主持一项国家自然科学基金青年基金项目(21302139/B020602)。


    完成的主要论文
 


     自
2000年至今,已在国内外学术刊物以第一作者、通讯作者或第二作者(通讯导师为第一作者)发表SCI收录论文20余篇。其中包括:RAPID COMMUN MASS SP; INT J MASS SPECTROM; APPL ORGANOMET CHEM; J ORGANOMET CHEM; BULL CHEM SOC JPN; BIOORGAN MED CHEM; J HETEROCYCLE CHEM; NUCLEOS NUCLEOT NUCL等国际杂志。在天津科技大学期间论文发表情况如下:

          (1) Wei Liu*, Yanling Guo, Cong Han, Shaoling Cheng; 1-(4-Nitrophenyl)pyrrolidine-2-carboxamide; Acta Crystallographica Section E2007, 6(5),  o2778-o2779.

         (2) Wei Liu*, Yanling Guo, Cong Han, Xiaonan Huang; Characteristic fragmentation behavior of 5-[1-aryl-1H-pyrrol-2-yl]-1H-tetrazole by electrospray ionization tandem mass spectrometry; Life Science Journal-ACTA ZHEN, 2008, 5(2), 25-29.

        (3) Wei Liu*, Yanting Tang, Yu Guo, Bo Sun, Hemin Zhu, Yanyan Xiao, Dandan Dong, Cheng Yang; Synthesis, characterization and bioactivity determination of ferrocenyl urea derivatives; Applied Organometallic Chemistry, 2012, 26, 189-193.

        (4) Wei Liu*, Lin Zhang, Honggang Zhou, Cheng Yang, Zhiwei Miao, Yufen Zhao; Synthesis of Novel Nucleoside Analogue Phosphorothioamidate Prodrugs and in vitro Anticancer Evaluation Against RKO Human Colon Carcinoma Cells; Nucleosides, Nucleotides and Nucleic Acids, 2013, 32, 161-173.

       (5) Dandan Dong, Yanyan Xiao, Wei Liu*, Honggang, Zhou, Cheng Yang. Progress in Kinase Aurora-B and its inhibitors; Acta Pharmaceutica Sinica, 2013, 48, 457-465.

      (6) Dazhi Liu, Zhen Tian, Zhihui Yan, Lixin Wu, Yan Ma, Quan Wang, Wei Liu*, Honggang Zhou, Cheng Yang; Design, synthesis and evaluation of 1, 2-benzisothiazol-3-one derivatives as potent caspase-3 inhibitors; Bioorganic & Medicinal Chemistry, 2013, 21, 2960-2967.

     (7) Sun Yuan-Pei, Zhang Ning, Wang Jian, Guo Yu, Sun Bo, Liu Wei*, Zhou Hong-Gang, Yang Cheng. Synthesis and Biological Evaluation of quinolinone compounds as SARS CoV 3CLpro inhibitors. Chinese J. Chem., 2013, 31, 1199-1206.

     (8) 朱贺敏,孙晓晓,刘伟*,周红刚,杨诚. 靶标Aurora A激酶结构、功能与抑制剂研究进展. 中国药学杂志20134810),753-758.

     (9) Sun Xiao-xiao, Sun Tao, Wang Tai-yi, Zhang Yan, Liu Hui-juan, Wang Quan, Niu Guo-jun, Liu Wei*, Zhou Hong-gang, Yang Cheng. Synthesis and Characterization of Pyrazoleanthrone Derivatives as Aurora A Kinase Inhibitors. Chem. Res. Chin. Univ., 2013, 29, 6: 1098-1103.

     (10) Wei Liu*, He-Min Zhu, Guo-Jun Niu, En-Zhi Shi, Jie Chen, Bo Sun, Wei-Qiang Chen, Hong-Gang Zhou, Cheng Yang. Synthesis, modification and docking studies of 5-sulfonyl isatin derivatives as SARS-CoV 3C-like protease inhibitors. Bioorganic & Medicinal Chemistry, 2014, 22, 292-302.

     (11) Lixin Wu, Meiqi Lu, Zhihui Yan, Xiaobin Tang, Bo Sun, Wei Liu*, Honggang Zhou, Cheng Yang. 1,2-Benzisothiazol-3-one derivatives as a novel class of small-molecule caspase-3 inhibitors. Bioorganic & Medicinal Chemistry, 2014, 22, 2416-2426.

     (12) Zhenghui Li, Yang Pan, Weilong Zhong, Yunpeng Zhu, Yongle Zhao, Lixin Li, Wei Liu*, Honggang Zhou, Cheng Yang. Synthesis and evaluation of N-acyl-substituted 1,2-benzisothiazol-3-one derivatives as caspase-3 inhibitors. Bioorganic & Medicinal Chemistry, 2014, 22, 6735-6745.

     (13) Zhenfei Guo, Zhihui Yan, Xiaowei Zhou, Quan Wang, Meiqi Lu, Wei Liu*, Honggang Zhou, Cheng Yang, Edward J. McClain Synthesis and biological evaluation of novel 1,2-benzisothiazol-3-one-derived 1,2,3-triazoles as caspase-3 inhibitors. Med Chem Res, 2015, 24: 1814-1829.

     (14) Wei Zhao, Wei Liu*. Progresses of Weinreb Amides in Organic Synthesis. Chinese Journal of Organic Chemistry, 2015, 35, 55-69.

     (15) Tang Xiaobin, Li Zhenghui, Li Yonghong, Liu Wei*, Yu Peng, Li Lixin, Guo Yu and Yang Cheng. Synthesis and Biological Evaluation of Novel Saccharin Derivatives Containing 1,2,3-Triazole Moiety. Chem. Res. Chin. Univ., 2015, 31(1), 71-77.

     (16) Zhou Xiaowei, Tang Yanting, Sang Feng, Wang Jinghan, Li lixin, Zhang Xiuli, Liu Wei*, Dai Yujie. Synthesis and Biological Evaluation of Phosphotyrosyl Mimetic as a Novel PTP1B Inhibitor. Chinese Journal of Organic Chemistry, 2015, 35(6), 1363-1369.


   专利申请
 


   1,2-
苯并异噻唑-3-1,2,3-三唑类衍生物及应用。申请号:2014101223774


   联系方式


   通信地址:天津市泰达开发区第十三大街
29号天津科技大学6号楼403

 

   邮政编码:300457

 

   手机:18920203098

 

   电 话:022-60600812

   E-mail liuwei2006@tust.edu.cn