个人基本情况

姓名：张秀兰

性别：女

出生年月：1984.07

职称职务：实验师

专业方向：有机化学、农药学

电话：022-60601481

教育经历：

2009-09至2014-06, 南开大学, 农药学, 硕博连读, 导师: 李正名

2004-09至2008-06, 河北师范大学, 化学, 学士

工作经历：

1. 2014.07-至今，天津科技大学，理学院，实验师

主要研究方向：

具有生物活性分子的设计、合成及构效关系研究

承担科研项目：

1. 天津市教委科研计划项目一般项目，2018KJ114，鱼尼丁受体杀虫剂与靶标作用位点的研究及绿色高效分子的创制，2018/10-2021/09，6万元，在研，主持

2. 天津市教委科研计划项目一般项目，2017KJ027，芯片型多功能化银纳米簇的制备及应用研究，2017/05-2020/04，6万元，结题，参与

3. 国家自然科学基金青年基金，21302104，具有新颖作用机理的鱼尼丁受体类绿色杀虫剂的设计合成及构效关系研究，2014/01-2016/12，25万元，结题，参与。

发表的论文：

1. Synthesis and Biological Evaluation of Novel Anthranilic Diamides Containing N-H/CH3-1H-Pyrazole, Chemical Research in Chinese Universities, 2020, 36(5): 829-834

2. Design, Synthesis and Biological Activities of Novel N-Aryl-1H-pyrazole-5-carboxylate Derivatives, Chemical Research in. Chinese Universities, 2020, 36(5): 853-858

3. Anthranilic diamides derivatives as potential ryanodine receptor modulators: synthesis, biological evaluation and structure activity relationship, Bioorganic and Medicinal Chemistry, 2018, 26(12): 3541-3550

4. Design, Synthesis, Biological Evaluation and SARs of Novel Anthranilic Diamides Derivatives Containing Amide, Carbamate, Urea, and Thiourea Moieties, Chinese Journal of Chemistry, 2017, 35(3): 368-374

5. Novel Anthranilic Diamide Scaffolds Containing N-Substituted Phenylpyrazole as Potential Ryanodine Receptor Activators, Journal of Agricultural and Food Chemistry, 2016, 64(18): 3697-3704

6. Synthesis and Insecticidal Evaluation of Novel N-Pyridylpyrazolecarboxamides Containing an Amino Acid Methyl Ester and Their Analogues, Journal of Agricultural and Food Chemistry, 2014, 62 (7): 1536-1542

7. Synthesis and Insecticidal Evaluation of Novel Anthranilic Diamides Containing N-Substitued Nitrophenylpyrazole, Bioorganic & Medicinal Chemistry, 2014, 22(1): 186-193

8. Design, Synthesis and Biological Activities of Novel Trifluoromethylated Phthalic Acid Diamides Derivatives, Chinese Journal of Organic Chemistry, 2014, 37(7): 1424-1428  

9. Syntheses and Biological Activities of Novel, 3-Bromo-1-(3-Chloropyridin-2-yl)-N-Hydroxy-N-Aryl-1H-Pyrazole-5-Carboxamides, Chemical Research in Chinese Universities, 2014, 30(3): 409-414

10. Synthesis and Biological Activity of Novel Anthranilic Diamides Containing N-Substituted Arylmethylene Moieties, Chemical Research in Chinese Universities, 2013, 29(6): 1134-1139

11. Design, Synthesis and Insecticidal Activity of 5-Chloro-N-(4-Chloro-2-(Substitutedcarbamoyl)-6-Methylphenyl)-1-Aryl-3-(Trifluoromethyl)-1H-Pyrazole-4-Carboxamide, Chemical Journal of Chinese Universities, 2013, 34(1): 96-102

12. Recent Advances in Cellulose Biosynthesis Inhibiting (CBI) Herbicides, World Pesticides, 2013, 35(2): 10-15

13. Synthesis and Insecticidal Evaluation of Novel N-Pyridylpyrazolecarboxamides Containing Cyano Substituent in the Ortho-Position, Bioorganic & Medicinal Chemistry Letters, 2013, 23(1): 42-46

14. Synthesis and Biological Activity of Novel 1-Substituted Phenyl(Glycosyl)-4-{4-[4,6-Dimethoxy)Pyrimidin-2-yl] Piperazin-1-yl}Methyl-1H-1,2,3-Triazoles, Chemical Research in Chinese Universities, 2013, 29(5): 900-905

15. Synthesis, Structure and Biological Activity of Novel 1,2,4-Triazole Mannich Bases Containing A Substituted Benzylpiperazine Moiety, Chemical Biology & Drug Design, 2011, 78(1): 42-49

专利：

(1) 李正名，张秀兰，马金龙，周莎，熊丽霞，李永强，王宝雷，一类取代苯基吡唑酰胺衍生物及其制备方法和应用，中国，CN103467380A

(2) 李正名，张秀兰，马金龙，周莎，熊丽霞，李永强，王宝雷，Class of substituted phenyl pyrazole amide derivatives and preparation method and use thereof，WO2015051572