个人基本情况
姓名：刘伟
出生年月：1978.03
职称职务：博士，教授，硕士生导师
专业方向：有机化学
教育经历：
1996.9-2000.7 天津师范大学化学系化学教育专业（本科）
2000.9-2003.7 南开大学元素所国家重点实验室（硕士）
2003.9-2006.7 清华大学化学系（博士）
2011.1-2013.4 天津国际生物医药联合研究院高通量药物筛选中心（博士后）
2013.12-2014.4 美国西弗吉尼亚大学化学系（访问学者）
工作经历：
2006.7-至今 天津科技大学理学院化学系有机化学教研室
主要研究方向：
药物化学（小分子信号通路抑制剂的研发）
有机合成（高价碘试剂研究）
有机电化学（卤素协助下的电催化有机反应研究；多组分电合成反应研究等）
有机分析（结构分析；质谱分析等）
主要承担科研项目：
2012.04至2013.10 开发白三烯水解酶调节剂研究。主持横向项目（1200110004），6万；
2013.01至2016.12 逆向合成指导的芳香化酶抑制剂全新药物设计和高通量虚拟筛选。国家自然科学面上基金项目第二参与人（21272171/B020601），80万；
2014.01至2016.12 苯并异噻唑酮类caspase-3抑制剂结构优化与生物活性评价。主持国家自然科学基金青年基金项目（21302139/B020602），25万；
2018.03至2020.03 小分子wnt/B-catenin 信号通路抑制剂的研发。主持横向项目（1800110001），20万；
2022.08至2025.07 电辅助医药(中间体)有机化学品合成工艺开发。主持横向项目（2200110003），20万；
发表论文情况：
自2000年至今，已在国内外学术刊物以第一作者或通讯作者发表SCI收录论文20余篇。其中包括：RAPID COMMUN MASS SP; INT J MASS SPECTROM; APPL ORGANOMET CHEM; J ORGANOMET CHEM; BULL CHEM SOC JPN; BIOORGAN MED CHEM; J HETEROCYCLE CHEM; NUCLEOS NUCLEOT NUCL; TETRAHEDRON; EUR J ORG CHEM等国际杂志。在天津科技大学期间发表SCI论文15余篇，近年SCI论文发表情况如下：
(1)Wei Liu*, Yanting Tang, Yu Guo, Bo Sun, Hemin Zhu, Yanyan Xiao, Dandan Dong, Cheng Yang. Synthesis, characterization and bioactivity determination of ferrocenyl urea derivatives; Applied Organometallic Chemistry, 2012, 26, 189-193.
(2) Dazhi Liu, Zhen Tian, Zhihui Yan, Lixin Wu, Yan Ma, Quan Wang, Wei Liu*, Honggang Zhou, Cheng Yang. Design, synthesis and evaluation of 1, 2-benzisothiazol-3-one derivatives as potent caspase-3 inhibitors; Bioorganic & Medicinal Chemistry, 2013, 21, 2960-2967.
(3) Wei Liu*, He-Min Zhu, Guo-Jun Niu, En-Zhi Shi, Jie Chen, Bo Sun, Wei-Qiang Chen, Hong-Gang Zhou, Cheng Yang. Synthesis, modification and docking studies of 5-sulfonyl isatin derivatives as SARS-CoV 3C-like protease inhibitors. Bioorganic & Medicinal Chemistry, 2014, 22, 292-302.
(4) Lixin Wu, Meiqi Lu, Zhihui Yan, Xiaobin Tang, Bo Sun, Wei Liu*, Honggang Zhou, Cheng Yang. 1,2-Benzisothiazol-3-one derivatives as a novel class of small-molecule caspase-3 inhibitors. Bioorganic & Medicinal Chemistry, 2014, 22, 2416-2426.
(5) Zhenghui Li, Yang Pan, Weilong Zhong, Yunpeng Zhu, Yongle Zhao, Lixin Li, Wei Liu*, Honggang Zhou, Cheng Yang. Synthesis and evaluation of N-acyl-substituted 1,2-benzisothiazol-3-one derivatives as caspase-3 inhibitors. Bioorganic & Medicinal Chemistry, 2014, 22, 6735-6745.
(6) Zhenfei Guo, Zhihui Yan, Xiaowei Zhou, Quan Wang, Meiqi Lu, Wei Liu*, Honggang Zhou, Cheng Yang, Edward J. McClain. Synthesis and biological evaluation of novel 1,2-benzisothiazol-3-one-derived 1,2,3-triazoles as caspase-3 inhibitors. Medicinal Chemistry Rearch, 2015, 24, 1814-1829.
(7) Wei Zhao, Wei Liu*. Progresses of Weinreb amides in organic synthesis. Chinese Journal of Organic Chemistry, 2015, 35, 55-69.
(8) Tang Xiaobin, Li Zhenghui, Li Yonghong,Liu Wei*, Yu Peng, Li Lixin, Guo Yu and Yang Cheng. Synthesis and biological evaluation of novel saccharin derivatives containing 1,2,3-triazole moiety. Chemical Research in Chinese Universities, 2015, 31(1), 71-77.
(9) Liu Wei*, Li Houying, Qin Haijuan, Zhao Wei, Zhou Chen, Jiang Shengping and Yang Cheng. Unexpected decarboxamidation of α--arylsulfonyl Weinreb amides by Grignard reagents: synthesis of α-disubstituted arylsulfones. Chemical Research in Chinese Universities, 2017, 33(2), 213-220.
(10) Wei Liu*, Wei Huang, Tianlei Lan, Haijuan Qin, Cheng Yang. Synthesis of a-benzylated amides via electrocatalytic Favorskii rearrangement of 1, 3-diarylacetones. Tetrahedron, 2018, 74, 2298-2305.
(11) Tianlei Lan, Haijuan Qin, Wenting Chen, Wei Liu*, Chao Chen*. Synthesis and reactivity of carbazole-containing hypervalent iodine(III) reagents. Chinese Chemical Letters, 2020, 31, 357-360.
(12) Yue Zhang, Jing Lu, Tianlei Lan, Shaoling Cheng, Wei Liu*, Chao Chen*. Preparation, characterization, and reactivity of aliphatic amino iodane(III) reagents. European Journal of Organic Chemistry, 2021, 3, 436-442.
(13) Zhenyu Wang, Chengyao Kimmy Cao, Evgeny Tretyakov, Wei Liu*, Chao Chen*. A facile stereoselective bis-trifluoromethylselenolation reaction of alkynes with AgSeCF3 and N-bromosuccinimide. Asian Journal of Organic Chemistry, 2022, 8(11), e202200319.
(14) Mengjia Zhao, Jiajia Fu, Yahui Sang, Zhenyu Wang, Wei Liu*, Chao Chen. Electrosynthesis of methyl 2-ureidobenzoates via a C2–C3 bond cleavage of isatins. Tetrahedron, 2023, 137, 133383.
